Kanye West is once again on a series of Twitter rants that, reportedly, profoundly affected his wife, Kim Kardashian. The Keeping Up with the Kardashians star is, now, dealing a lot again with her husband's mental health issue.

An insider told Us Weekly Kardashian is "deeply disappointed and sad," seeing West is "struggling." Although the 43-year-old rapper's public meltdown seems to turn into a "vicious cycle," the reality star has triumphantly succeeded over it "for months at a time."

The insider continued the 39-year-old television personality "isn't surprised" that the presidential hopeful isn't following their discussed "care plan," which attributed to his "downward spiral" due to the COVID-19 pandemic. It's never healthy for West to be "isolated and alone," especially in his head.

This, allegedly, put the couple at odds again, according to People. Previously, the two were on the brink of a divorce, but they managed to reconnect after spending some family time together with their kids.

However, with his latest Twitter meltdown, their relationship took a 360-degree turn. Recently, Twitter banned West after he violated its rule of posting a screenshot of a Forbes editor's phone number.

He also shared a clip where he peed on one of his Grammy awards. A source told People these things put Kardashian at the "end of her rope again."

West is said to be "off his meds," although he promised to stick on it. In their so-called care plan, part of his negotiation with the SKIMS founder was to get back on his medication.

He, too, vowed to "work very hard to control his impulses." Sadly, all the promises he made were all broken just less than a month later.

West and Kardashian have had a lot of ups and downs as of late. After he announced his presidential bid in July, he had his first Twitter rants, accusing Kardashian of cheating.

He, too, called out his mother-in-law, Kris Jenner. The fashion mogul also revealed some private details about his family in a presidential rally.

The insider continued the KKW Beauty owner didn't mind the tweets, believing it was just West being himself. However, it's the mood swings and manic episodes that made it all the more difficult for her to help him cope.

Amid the rumors, Kardashian remained to be patient, giving him the space he needed. She let West be creative, hoping it would be a "healthy outlet for him to express himself." However, the source explained her best intentions seemed to result in "negative outcomes."