The tragic demise of Matthew Perry, renowned for his role as Chandler Bing on the popular sitcom "Friends," has left fans and the entertainment industry in deep sorrow. Perry's final days were marked by a complex mix of emotions and substances, as detailed in the autopsy report released on December 15. The report reveals a troubling picture of the star's physical and mental state leading up to his untimely death.

According to the autopsy, Perry was struggling with a mix of medications, including testosterone shots, ketamine, and various other prescription drugs. These substances were found to have significantly impacted his mood and behavior, with a friend of Perry describing him as "angry and mean" in the weeks before his death. This change in demeanor was particularly linked to the testosterone shots he was receiving.

Perry was attempting to quit smoking and had been using nicotine lollipops to aid in this process. However, his assistant noted that he was still consuming around two packs of cigarettes per day. His reliance on prescribed and over-the-counter medications was evident, as his assistant's bedroom contained multiple open, empty, and half-filled medication bottles prescribed to Perry.

The report further disclosed that Perry was regularly receiving ketamine infusions before his passing, but the fatal dose was likely self-administered. Dr. Bankole Johnson, a top neuroscientist and physician, suggested that the ketamine found in Perry's system at the time of his death was likely due to recreational use, considering ketamine's half-life is only a few hours.

Perry's history with substance abuse was well-documented, and he had openly discussed his struggles in his 2022 memoir, "Friends, Lovers, and the Big Terrible Thing: A Memoir." In his book, he described ketamine infusions as feeling like a "giant exhale," a temporary escape from reality that felt akin to dying. Despite this, he concluded that ketamine was not suitable for him.

The beloved actor's death was ruled as an accident, caused by the acute effects of ketamine and subsequent drowning. He was found in his hot tub, and the medical examiner's report indicated no evidence of foul play. The report also mentioned that Perry had been clean and sober for 19 months leading up to his death.

In the wake of his passing, Perry's contributions to the fight against addiction have been highlighted. The Matthew Perry Foundation, launched days after his death, aims to assist individuals battling addiction. Perry had also founded the Perry House in 2013 to support others in their sobriety journey.

Perry's death has not only shocked his fans and loved ones but has also brought to light the challenges faced by individuals struggling with addiction and mental health issues. His legacy as an actor and advocate continues to resonate, reminding us of the profound impact that public figures can have in raising awareness and supporting those in need.